Evaluation of Antibody Responses to Multivalent Vaccines

Recent efforts in the vaccine field in the context of several pathogens, including dengue, influenza, and HIV-1 have focused on the development of multivalent vaccines that incorporate antigen diversity within the vaccine formulation, as an approach for eliciting antibody responses with high neutralization breadth. For a given multivalent vaccine, LIBRA-seq can be applied to generate high-resolution maps of antibody-antigen specificity, providing insights into the reactivity of the individual vaccine components, and leading to strategies for optimization of vaccine composition.