Personalized Profiling of Human Antibody Repertoires

At the level of single individuals, LIBRA-seq can be applied to create personalized immune profiles that link B cell repertoires to specificity toward common antigens encountered throughout an individual’s lifetime. Over time, each individual experiences antigen exposure from various sources, including common infections and vaccinations, commensal microorganisms, and self- and neoantigens. LIBRA-seq provides a unique opportunity to promote personalized medicine approaches in the context of such common antigens.